Alaxan FR Adverse Reactions

Ibuprofen-paracetamol, when taken within therapeutic levels, have low incidence of side effects. No serious adverse effects have been reported to date. Only minor allergic type reactions eg, skin rashes which is expected with any other NSAIDs like aspirin, etc, have been reported.
Ibuprofen-paracetamol shares the same adverse effects as other NSAIDs:
GI Effects: Like all other NSAIDs, the most frequent adverse effects of ibuprofen involves the GI tract and include: Gastric mucosal damage resulting in ulceration and/or mucosal bleeding; other GI effects are dyspepsia, heartburn, nausea, vomiting, anorexia, diarrhea, constipation, stomatitis, flatulence, bloating, epigastric and abdominal pain.
Renal Effects: Acute renal failure with acute tubular necrosis, polyuria, increase urea and BUN in the blood (azotemia), cystitis, hematuria and decreased creatinine clearance have been reported.
Hepatic Effects: Jaundice and transient increase in serum AST (SGOT), ALT (SGPT) and serum alkaline phosphatase have occurred in few patients during NSAID therapy including ibuprofen.
Hematologic Effects: Neutropenia, agranulocytosis, aplastic anemia, hemolytic anemia and thrombocytopenia have been reported.
CNS Effects: Dizziness, drowsiness, malaise, lightheadedness, nervousness, headache, fatigue, emotional lability, paresthesia, hallucinations, dream abnormalities and pseudotumor cerebri have been reported.
Otic and Ocular Effects: Tinnitus, decreased hearing, amblyopia, conjunctivitis, optic neuritis, diplopia and cataracts have been reported.
Dermatologic Effects: Urticaria, vesiculobullous, erythematous macular rashes, erythema multiforme, exfoliative dermatitis, toxic epidermal necrolysis and photosensitivity.
Others: Fluid retention, increased blood pressure, hypotension, cerebrovascular accident and palpitations have been reported.